Three-Component Glycolate Michael Reactions of Enolates, Silyl Glyoxylates, and α,β-Enones

Three-component coupling reactions of silyl glyoxylates, vinyl Grignard reagent, and nitroalkenes: an efficient, highly diastereoselective approach to nitrocyclopentanols.

The efficient synthesis of highly substituted cyclopentanols is an important task given the prevalence of this class of compounds in nature. Nitrocyclopentanols are of particular value due to the rich chemistry associated with the nitro group and their potential use as aminocyclopentitol progenitors. Aminocyclopentitols have generated considerable attention because of their significant biologic...

Palladium(II)-catalyzed stereospecific three-component domino reactions of diyne-enones, nucleophiles, and vinyl ketones.

An efficient and inexpensive catalyst system for the aza-Michael reactions of enones with carbamates.

A new strategy which uses very cheap FeCl3 as an effective catalyst in the presence of Me3SiCl has been developed for the conjugate addition of enones and chalcone with unactivated weakly nucleophilic carbamates.

Chiral Sc-catalyzed asymmetric Michael reactions of thiols with enones in water.

Asymmetric Michael reactions of thiols with enones were catalyzed by a Sc(OTf)(3)-chiral bipyridine complex at room temperature in water without using any organic solvents, to afford the desired sulfides in high yields with high enantioselectivities.

Transition metal salts-catalyzed aza-Michael reactions of enones with carbamates.

Several transition metal salts were found to catalyze aza-Michael reactions of enones with carbamates efficiently. The catalytic activity was strongly dependent on the nature of the metal salts. While conventional Lewis acids such as BF(3).OEt(2), AlCl(3), or TiCl(4) showed lower activity, group 7-11 transition metal salts in higher oxidation states such as ReCl(5), Fe(ClO(4))(3).9H(2)O, RuCl(3...